Selected publications related to neurosteroid-induced synaptic plasticty

L.Fester, Gabriele M.Rune (2021), Sex neurosteroids: Hormones made by the brain for the brain Neurosci Lett 2021 Mar 26;753:135849. doi: 10.1016/j.neulet.2021.135849. Online ahead of print.

Nicola Brandt, Tobias Löffler, Lars Fester, Gabriele M Rune (2020), Sex-specific features of spine densities in the hippocampus Sci Rep. 2020 Jul 9;10(1):11405. doi: 10.1038/s41598-020-68371-x.

N Brandt, L Fester, G M Rune (2020), Neural sex steroids and hippocampal synaptic plasticity Vitam Horm. 2020;114:125-143. doi: 10.1016/bs.vh.2020.06.001. Epub 2020 Jul 3.

Iris Haumann, Muriel Anne Sturm, Max Anstötz, Gabriele M Rune (2020), GPER1 Signaling Initiates Migration of Female V-SVZ-Derived Cells iScience. 2020 May 22;23(5):101077. doi: 10.1016/j.isci.2020.101077. Epub 2020 Apr 18.

Nicola Brandt, Ricardo Vierk, Lars Fester, Max Anstötz, Lepu Zhou, Lukas F Heilmann, Simon Kind, Paul Steffen, Gabriele M Rune (2020), Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids Cereb Cortex. 2020 Apr 14;30(4):2627-2641. doi: 10.1093/cercor/bhz265.

Nicola Brandt, Gabriele M Rune (2019), Sex-dependency of oestrogen-induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents Eur J Neurosci. 2020 Jul;52(1):2548-2559. doi: 10.1111/ejn.14541. Epub 2019 Aug 31.

Tobias Sommer, Katharina Richter, Franziska Singer, Birgit Derntl, Gabriele M Rune, Esther Diekhof, Janine Bayer (2019), Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women Psychopharmacology (Berl). 2018 Dec;235(12):3465-3477. doi: 10.1007/s00213- 018-5061-y. Epub 2018 Oct 10.

Maurice Meseke, Florian Neumüller, Bianka Brunne, Xiaoyu Li, Max Anstötz, Theresa Pohlkamp, Meike M Rogalla, Joachim Herz, Gabriele M Rune, Roland A Bender (2018), Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. eNeuro. 2018 Oct 15;5(5):ENEURO.0258-18.2018. doi: 10.1523/ENEURO.0258- 18.2018. eCollection Sep-Oct 2018.

Bender R, Zhou L, Vierk R, Brandt N, Keller A, Gee C, Schäfer M, Rune G (2017), Sex-dependent regulation of aromatase-mediated synaptic plasticity in the basolateral amygdala.J Neurosci 37(6):1532-1545.

Fester L, Zhou L, Ossig C, Labitzke J, Bläute C, Bader M, Vollmer G, Jarry H, Rune G (2017), Synaptopodin is regulated by aromatase activity. J Neurochem 140(1):126-139

Fester L, Brandt N, Windhorst S, Pröls F, Bläute C, Rune G (2016), Control of aromatase in hippocampal neurons. J Steroid Biochem 160:9-14.

Prange-Kiel J, Dudzinski D, Pröls F, Glatzel M, Matschke J, Rune G (2016), Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice. Neural Plast doi: 10.1155/2016/9802086

Ruiz-Palmero I, Ortiz-Rodriguez A, Melcangi R, Caruso D, Garcia-Segura L, Rune G, Arevalo M (2016), Oestradiol synthesized by female neurons generates sex differences in neuritogenesis. Sci Rep UK doi: 10.1038/srep31891.

Vierk R, Bayer J, Freitag S, Muhia M, Kutsche K, Wolbers T, Kneussel M, Sommer-Blöchl T, Rune G (2015), Structure-function-behavior relationship in estrogen-induced synaptic plasticity. Horm Behav. 74:139-48

Zhou L, Fester L, Haghshenas S, de Vrese X, von Hacht R, Gloger S, Brandt N, Bader M, Vollmer G, Rune G (2014), Oestradiol-induced synapse formation in the female hippocampus: roles of oestrogen receptor subtypes. Journal of Neuroendocrinology 26(7):439-47

Fester L, Labitzke J, Hinz R, Behem C, Horling K, Bernhard T, Bader M I, Vollmer G, Rune GM (2013), Estradiol responsiveness of synaptopodin in hippocampal neurons is mediated by estrogen receptor ß. J Steroid Biochem. Mol. Biol. 138:455-461

Prange-Kiel J, Schmutterer T, Fester L, Zhou L, Imholz P, Brandt N, Vierk R, Jarry H, Rune GM (2013), Endocrine regulation of estrogen synthesis in the hippocampus? Prog Histochem cytochem 48(2):49-64

Brand N, Vierk R, Rune GM (2013), Sexual dimorphism in estrogen-induced synaptogenesis in the adult hippocampus. Int J Dev Biol 57(5):351-6

Bayer J, Rune G, Kutsche K, Schwarze U, Kalisch R, Büchel C, Sommer T (2013), Estrogen and the male hippocampus: Genetic variation in the aromatase gene predicting serum estrogen is associated with hippocampal gray matter volume in men. Hippocampus 23(2):117-21

Beyer C, Rune G (2012), Steroids in the brain: regulators of brain plasticity and protectors against neuronal damage., J Steroid Biochem Mol Biol 131(1-2):1

Vierk R, Glassmeier G, Zhou L, Brandt N, Fester L, Dudzinski D, Wilkars W, Bender RA, Lewerenz M, Gloger S, Graser L, Schwarz J, Rune GM (2012), Aromatase Inhibition Abolishes LTP Generation in Female But Not in Male Mice. J. Neurosci 32(24):8116-8126

Fester L, Prange-Kiel J, Zhou L, von Blittersdorf B, Böhm J, Jarry H, Schumacher M, Rune GM (2012), Estrogen-regulated synaptogenesis: sexual dimorphism in vivo but not in vitro. J Steroid Biochem Mol Biol 131(1-2):24-29

Fester L, Prange-Kiel J, Jarry H, Rune GM (2011), Estrogen synthesis in the hippocampus. Cell Tissue Res. 345(3):285-94

Bender RA, Zhou L, Wilkars W, Fester L, Lanowski JS, Paysen D, König A, Rune GM (2010), Roles of 17ß-estradiol involve regulation of reelin expression and synaptogenesis in the dentate gyrus. Cereb Cortex. 20(12):2985-95

Zhou L, Fester L, von Blittersdorff B, Hassu B, Nogens H, Prange-Kiel J, Jarry H, Wegscheider K, Rune GM (2010), Aromatase inhibitors induce spine synapse loss in the hippocampus of ovariectomized mice. Endocrinology. 151(3):1153-60

Fester L, Zhou L, Voets C, Ossig C, Disteldorf E, Bläute F, Prange-Kiel J, Dudzinski D, Jarry H, Rune GM (2009), The opposing roles of estradiol on synaptic protein expression in hippocampal cultures. Psychoneuroendocrinology 34 Suppl 1:123-9.

Prange-Kiel J, Fester L, Zhou L, Jarry H, Rune GM (2009) Estrus cyclicity of spinogenesis: underlying mechanisms. J Neural Transm 116(11):1417-25. 

Fester L, Zhou L, Bütow A, Huber C, von Lossow R, Prange-Kiel J, Jarry H, Rune GM (2009), Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus.Hippocampus 19(8):692-705

Prange-Kiel J, Jarry H, Schoen M, Kohlmann P, Lohse C, Zhou L, Rune GM (2008), Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis.J Cell Biol 180(2):417-26

Zhou L, Lehan N, Wehrenberg U, Disteldorf E, von Lossow R, Mares U, Jarry H, Rune GM (2007), Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors. Exp Neurol 203(1):72-81

Prange-Kiel J, Fester L, Zhou L, Lauke H, Carrétero J, Rune GM (2006) Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons. Hippocampus 16(5):464-71

Kretz O, Fester L, Wehrenberg U, Zhou L, Brauckmann S, Zhao S, Prange-Kiel J, Naumann T, Jarry H, Frotscher M, Rune GM (2004), Hippocampal synapses depend on hippocampal estrogen synthesis. J Neurosci 24(26):5913-21

Prange-Kiel J, Rune GM, Leranth C (2004), Median raphe mediates estrogenic effects to the hippocampus in female rats. Eur J Neurosci 19(2):309-17

Prange-Kiel J, Wehrenberg U, Jarry H, Rune GM (2003), Para/autocrine regulation of estrogen receptors in hippocampal neurons. Hippocampus

Rune, GM, Frotscher, M (2005), Neurosteroid synthesis in the hippocampus: Role in synaptic plasticity. Neuroscience 136:833-42

Rune GM, Wehrenberg U, Prange-Kiel J, Zhou L, Adelmann G, Frotscher M (2002), Estrogen up-regulates estrogen receptor alpha and synaptophysin in slice cultures of rat hippocampus. Neuroscience 113:167-75

Wehrenberg U, Prange-Kiel J, Rune GM (2001), Steroidogenic factor-1 expression in marmoset and rat hippocampus: co-localization with StAR and aromatase. J Neurochem 76:1879-8